Each of these apps comes close. TweetDeck combines Twitter and Facebook status updates in one desktop-space-stealing application while Tweetie focuses only on Twitter. But I would love to have them combined.

Can we get the power of TweetDeck smooshed into a Tweetie-sized footprint? TweetDeck has a cool feature that let’s you group people you follow and display them separately — I use it to see “local” posts. But that adds yet another column to the interface. Why do I need a complete column for Replies, Tag Cloud, and Direct Messages?

Tweetie supports multiple accounts and has a much cleaner interface. The memory usage is also much better than TweetDeck. Because it’s a Cocoa app (TweetDeck is built on Adobe’s AIR platform), Tweetie feels snappier and uses some CoreAnimation effects to pretty things up.

With the flurry of Twitter clients — I personally have used twitter.com, Nambu, Twitterific, TweetDeck, Tweetie, Seesmic Desktop, even an Adium plug-in — I have to believe we’re getting close to The Perfect One.